My grandpa has given up. I'm just in shock, I'm 1000 miles away, what can I possibly say to him?

I'm sorry to hear about this. To me it sounds like he is going through depression. Maybe you could advise him to talk to someone about it and perhaps see a therapist. also there are other things in life to enjoy besides seeing things. You could tell him to "enjoy the little things like grandma's warm embracing hugs, the sound of the birds chirping in the morning, the smell of a tasty meal, the melody of a song" I also think it would be a good idea to mail him some CD's that he could listen to. Perhaps his favorite artist or band :) I think he would like that. Good luck!